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GPX Panel

Our multiplexed nucleic acid testing verifies the existence of the following pathogens with one stool specimen in a singular test.

Bacteria and Toxins by PCR

Parasites by PCR
Viruses by PCR
  • Adenovirus 40/41
  • Norovirus GI/GII
  • Rotavirus A

The GPX is a multiplexed nucleic acid test that is designed to identify 14 various bacteria, parasites and viruses in the digestive system. Using this cutting edge PCRtechnology, this panel has the capability of detecting multiple pathogens within a single test run and provides the provider with sensitivity and specificity results of the highest standard. GPX test simultaneously detects and identifies the pathogens responsible for over 95% of cases of infectious diarrhea1. Indicated uses for GPX: 

  • Acute and chronic diarrhea
  • All patients with symptoms and signs of infectious gastroenteritis or colitis
  • Inpatient, outpatient and emergency settings
  • Nosocomial surveillance

Specimen: Stool DNA

Collection and transportation

Stool sample collected by the patient or client and transported in the provided DRG stool/biopsy container (10mL Saline-0.85% NaCl) at room temperature and extracted by DRG Laboratory.

Methodology

Multiplex PCR (polymerase chain reaction) and hybridization technology When ordering the GPX test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. With advanced PCR technologies, it is possible to measure hundreds of organisms, literally taking billions of copies of an individual’s DNA. Please contact us at customerservice@drglab.com or at (678)580-0613 – option 2.

CPT Code: 87507

(Infectious agent detection by nucleic acid (DNA or RNA); gastrointestinal pathogen (eg, Clostridium difficile, E. coli, Salmonella, Shigella, norovirus, Giardia), includes multiplex reverse transcription, when performed, and multiplex amplified probe technique, multiple types or subtypes, 12-25 targets)

ICD-10 Code Description
A02.0 Salmonella enteritis
A03.0 Shigellosis due to Shigella dysenteriae
A04.0 Enteropathogenic Escherichia coli
A04.72 Enterocolitis due to Clostridium diff
A07.1 Giardiasis [lambliasis]
K52.9 Noninfective gastroenteritis and colitis

GI Health Markers

Our GI inflammatory health markers provide detailed information about possible inflammation that could occur in the digestive system.

Our GI inflammatory health markers are an invaluable resource for providers to determine the patient’s condition of Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). IBS and IBD are both chronic illnesses and share many of the same symptoms, however, each is treated differently. If not diagnosed correctly, serious effects could arise from both illnesses. Providers can select from our complete offering of protein markers to fully understand if inflammation exists throughout the entire digestive system. If providers are concerned with specific areas within the digestive system, individual markers can be selected for precise inflammation detection. These markers provide an abundance of information and has the highest sensitivity and specificity results of any digestive test available. When ordering the GI Health Markers test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. With advanced PCR technologies, it is possible to measure hundreds of organisms, literally taking billions of copies of an individual’s DNA. Please contact us at customerservice@drglab.com or at (678)580-0613 – option 2.

CPT Codes

  • Anti-gliadin: 82784
  • Calprotectin: 83993
  • Fecal Fat: 83690
  • Fecal Occult Blood: 82274
  • H. pylori stool antigen: 87739
  • Lactoferrin: 83361
  • Pancreatic Elastase: 82656
ICD-10 Code Description Associated Test
A04.7 Clostridium difficile Lactoferrin
K51.80 Ulcerative colitis Lactoferrin
K58.0 Irritable Bowel Syndrome Calprotectin
K50.90 Crohn’s disease Calprotectin
K90.0 Celiac disease Anti-Gliadin/Fecal Fat
K90.41 Non-celiac gluten sensitivity Anti-Gliadin/Fecal Fat
K29.0 Acute gastritis with bleeding H. Pylori SA
K27.0 Acute peptic ulcer, site unspecified H. Pylori SA
K80.10 Exocrine pancreatic insufficiency Elastase
K85.10 Other specified diseases of pancreas Elastase

C. difficile Only Panel

Our C. difficile only assay specifically detects toxin A positive or toxin B positive strains or both.

  • C. difficile toxin A
  • C. difficile toxin B
We test for Clostridium difficile using two molecular methodologies. First is the multiplex assay platform (see GPX Panel), that is designed to test for many GI pathogens (including C.difficile), parasites and viruses using PCR and DNA Hybridization methods on DNA extracted from patient stool samples. The second test is a C. difficile only assay, that specifically targets the C. difficile toxin A gene (tcdA) and toxin B gene (tcdB) with real-time PCR chemistry and is able to detect the presence of this bacterium from stool samples in just a few hours. With the C. difficile only Assay, we are able to specifically detect toxin A positive or toxin B positive strains or both. In house comparison studies have shown good correlation between the two methodologies in detecting C.difficile from patient stool samples. The two platforms of molecular testing allow for flexibility: 1) if the doctor requires only C.difficile testing  or 2) a more expanded panel of analytes to be tested for a patient, they will able choose the platform to meet their requirements. When ordering the C. difficile only test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. With advanced PCR technologies, it is possible to measure hundreds of organisms, literally taking billions of copies of an individual’s DNA. Please contact us at customerservice@drglab.com or at (678)580-0613 – option 2.

CPT Code: 87493 – C diff amplified probe (MUE-2)

ICD-10 Code Description
A04.71 Enterocolitis due to Clostridium difficile, recurrent
A04.72 Enterocolitis due to Clostridium difficile, not specified as recurrent
Z11.0 Encounter for screening for intestinal infectious Diseases
Z11.2 Encounter for screening for other bacterial Diseases

Antibiotic Resistance Panel

In our Antibiotic Resistance Panel we assess Antibiotic Resistant genes in patient stool samples using molecular methods that offer several advantages

  • ß-lactamase (bla-TEM)
  • Nitroimidazole (nimD)
  • Imidazole (nimA)
  • Vancomycin (vanA)
  • Vancomycin (vanB)
  • Fluoroquinolones (qnr)
Susceptibility to antimicrobial agents is determined by phenotypic or genotypic methods. The phenotypic development of resistance is detected by performing in vitro susceptibility testing. Testing for altered sensitivity to antimicrobial agents is of clinical significance especially when organisms persists in patients being treatment with antimicrobial agents that are generally considered effective against particular isolate. Phenotypic methods are generally used for aerobic bacteria, some mycobacteria and yeast. At DRG Labs we assess Antibiotic Resistant genes in patient stool samples using molecular methods that offer several advantages as discussed below.
Molecular methods that detect genes directly involved in the resistance of an organism to a particular agent offer a more straightforward prediction of antibiotic resistance.
There are four reasons for using molecular methodologies:
  1. When an organism has an MIC at or near the breakpoint of resistance, detection of mutated genes, contributing to resistance would be irrefutable evidence of the potential ineffectiveness of the agent.
  2. Genes involved in the resistance of organisms to antimicrobial agents can be detected directly in the clinical specimen closer to time of collection and save time required to isolate the organism and perform phenotypic MIC determinations on isolated colonies.
  3. Monitoring the spread of resistance genes in multiple isolates of the same organism is more useful in epidemiological investigations than following the trend in MIC.
  4. Molecular methods are considered the gold standard when new phenotypic assay is being developed.
When ordering the Antibiotic Resistance test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. With advanced PCR technologies, it is possible to measure hundreds of organisms, literally taking billions of copies of an individual’s DNA. Please contact us at customerservice@drglab.com or at (678)580-0613 – option 2.

CPT Code: 87798 – Detect agent nos dna amp MUE(6)

ICD-10 Code Description
Z16.12 Extended spectrum beta lactamase (ESBL) resistance
Z16.19 Resistance to other specified beta lactam antibiotics
Z16.21 Resistance to vancomycin
Z16.22 Resistance to vancomycin related antibiotics
Z16.23 Resistance to quinolones and fluoroquinolones
Z16.24 Resistance to multiple antibiotics
Z16.29 Resistance to other single specified antibiotic
Z16.31 Resistance to antiparasitic drug(s)
Z16.32 Resistance to antifungal drug(s)
Z16.33 Resistance to antiviral drug(s)
Z16.34 Resistance to antimycobacterial drug(s)
Z16.341 Resistance to single antimycobacterial drug
Z16.342 Resistance to multiple antimycobacterial drugs
Z16.35 Resistance to multiple antimicrobial drugs
Z16.39 Resistance to other specified antimicrobial drug
Z16.12 Extended spectrum beta lactamase (ESBL) resistance

Helicobacter (H. pylori) Test

Our PCR based detection of Helicobacter pylori can serve as a powerful tool in diagnosis of Helicobacter pylori infection and as a determinant for treatment efficacy.

  • Helicobacter pylori (H. pylori)
Polymerase chain reaction – PCR allows researchers and clinicians to identify H. pylori in small samples that have few bacteria present. It does not require any special processing supplies or transportation, and it can be performed on samples obtained by both invasive and noninvasive methods. Moreover, PCR can be performed faster than many other diagnostic methods, used to identify diverse bacterial genotypes, and employed in epidemiological studies. A considerable drawback of PCR is that it can detect DNA segments of dead bacterium in the gastric mucosa of patients after treatment; consequently, it can produce false-positive results. Molecular detection of H. pylori using PCR is possible in materials obtained by non- or minimally invasive procedures, such as gastric juice, gastric content, saliva, stools, etc. Thus, molecular methods can be easily applied to specimens obtained by string tests or orogastric brushes. Molecular testing may be of particular value for samples that can no longer be successfully cultured because of prolonged transport or in cases where isolation of H. pylori is not feasible as a result of contamination.
When ordering the H. pylori test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. With advanced PCR technologies, it is possible to measure hundreds of organisms, literally taking billions of copies of an individual’s DNA. Please contact us at customerservice@drglab.com or at (678)580-0613 – option 2.

CPT Code: 87798 – Detect agent nos dna amp (H. pylori)

ICD-10 Code Description
K27.0 Acute peptic ulcer, site unspecified, with hemorrhage
K27.1 Acute peptic ulcer, site unspecified, with perforation
K27.2 Acute peptic ulcer, site unspecified, with both hemorrhage and perforation
K27.3 Acute peptic ulcer, site unspecified, without hemorrhage or perforation
K27.4 Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage
K27.5 Chronic or unspecified peptic ulcer, site unspecified, with perforation
K27.6 Chronic or unspecified peptic ulcer, site unspecified, with both hemorrhage and perforation
K27.7 Chronic peptic ulcer, site unspecified, without hemorrhage or perforation
K27.9 Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
K29.0 Acutegastritis
K29.00 Acute gastritis without bleeding
K29.01 Acute gastritis with bleeding
K29.2 Alcoholic gastritis
K29.20 Alcoholic gastritis without bleeding
K29.21 Alcoholic gastritis with bleeding
K29.3 Chronic superficial gastritis
K29.4 Chronic atrophic gastritis
K29.5 Unspecified chronic gastritis
K29.6 Othergastritis
K29.7 Gastritis,unspecified
K29.8 Duodenitis
K29.9 Gastroduodenitis,unspecified
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